Based on this tutorial

Integrating a Modern JavaScript Pipeline into a Django Application

Django setup

pip install django

django-admin startproject mysite

python manage.py startapp myapp

python manage.py migrate

python manage.py runserver

Webpack setup

npm init -y
npm install webpack webpack-cli --save-dev

npm run dev

Connecting webpack bundles to Django

Run Django server

http://localhost:8000/hello-webpack/

Setting up React with Babel

npm install --save-dev babel-loader @babel/core @babel/preset-env @babel/preset-react

npm install --save react react-dom

npm run dev