diff --git a/addons/point_of_sale/models/pos_order.py b/addons/point_of_sale/models/pos_order.py
index 0ee918a704d9d..3c53eb4026ec3 100644
--- a/addons/point_of_sale/models/pos_order.py
+++ b/addons/point_of_sale/models/pos_order.py
@@ -1388,7 +1388,7 @@ def get_existing_lots(self, company_id, product_id):
             filtered(lambda q: float_compare(q.quantity, 0, precision_rounding=q.product_id.uom_id.rounding) > 0).\
             mapped('lot_id')
 
-        return available_lots.read(['id', 'name'])
+        return available_lots.read(['id', 'name', 'product_qty'])
 
     @api.ondelete(at_uninstall=False)
     def _unlink_except_order_state(self):
diff --git a/addons/point_of_sale/static/src/app/store/pos_store.js b/addons/point_of_sale/static/src/app/store/pos_store.js
index af841b95ffb66..c8ede31c4d41a 100644
--- a/addons/point_of_sale/static/src/app/store/pos_store.js
+++ b/addons/point_of_sale/static/src/app/store/pos_store.js
@@ -1884,6 +1884,38 @@ export class PosStore extends Reactive {
             canCreateLots = true;
         }
 
+        const usedLotsQty = this.models["pos.pack.operation.lot"]
+            .filter(
+                (lot) =>
+                    lot.pos_order_line_id?.product_id?.id === product.id &&
+                    lot.pos_order_line_id?.order_id?.state === "draft"
+            )
+            .reduce((acc, lot) => {
+                if (!acc[lot.lot_name]) {
+                    acc[lot.lot_name] = { total: 0, currentOrderCount: 0 };
+                }
+                acc[lot.lot_name].total += lot.pos_order_line_id?.qty || 0;
+
+                if (lot.pos_order_line_id?.order_id?.id === this.selectedOrder.id) {
+                    acc[lot.lot_name].currentOrderCount += lot.pos_order_line_id?.qty || 0;
+                }
+                return acc;
+            }, {});
+
+        // Remove lot/serial names that are already used in draft orders
+        existingLots = existingLots.filter((lot) => {
+            return lot.product_qty > (usedLotsQty[lot.name]?.total || 0);
+        });
+
+        // Check if the input lot/serial name is already used in another order
+        const isLotNameUsed = (itemValue) => {
+            const totalQty = existingLots.find((lt) => lt.name == itemValue)?.product_qty || 0;
+            const usedQty = usedLotsQty[itemValue]
+                ? usedLotsQty[itemValue].total - usedLotsQty[itemValue].currentOrderCount
+                : 0;
+            return usedQty ? usedQty >= totalQty : false;
+        };
+
         const existingLotsName = existingLots.map((l) => l.name);
         const payload = await makeAwaitable(this.dialog, EditListPopup, {
             title: _t("Lot/Serial Number(s) Required"),
@@ -1893,6 +1925,7 @@ export class PosStore extends Reactive {
             options: existingLotsName,
             customInput: canCreateLots,
             uniqueValues: product.tracking === "serial",
+            isLotNameUsed: isLotNameUsed,
         });
         if (payload) {
             // Segregate the old and new packlot lines
diff --git a/addons/point_of_sale/static/src/app/store/select_lot_popup/select_lot_popup.js b/addons/point_of_sale/static/src/app/store/select_lot_popup/select_lot_popup.js
index 3ece3cb4fb2db..d3270b6ba2952 100644
--- a/addons/point_of_sale/static/src/app/store/select_lot_popup/select_lot_popup.js
+++ b/addons/point_of_sale/static/src/app/store/select_lot_popup/select_lot_popup.js
@@ -45,11 +45,13 @@ export class EditListPopup extends Component {
         options: { type: Array, optional: true },
         customInput: { type: Boolean, optional: true },
         uniqueValues: { type: Boolean, optional: true },
+        isLotNameUsed: { type: Function, optional: true },
     };
     static defaultProps = {
         options: [],
         customInput: true,
         uniqueValues: true,
+        isLotNameUsed: () => false,
     };
 
     /**
@@ -121,6 +123,7 @@ export class EditListPopup extends Component {
     }
     hasValidValue(itemId, text) {
         return (
+            !this.props.isLotNameUsed(text) &&
             (this.props.customInput || this.props.options.includes(text)) &&
             (!this.props.uniqueValues ||
                 !this.state.array.some((elem) => elem._id !== itemId && elem.text === text))
@@ -186,6 +189,7 @@ export class EditListPopup extends Component {
                     const itemValue = item.text.trim();
                     const isValidValue =
                         itemValue !== "" &&
+                        !this.props.isLotNameUsed(itemValue) &&
                         (this.props.customInput || this.props.options.includes(itemValue));
                     if (!isValidValue) {
                         return false;
diff --git a/addons/point_of_sale/static/tests/tours/ticket_screen_tour.js b/addons/point_of_sale/static/tests/tours/ticket_screen_tour.js
index e22a5649651f9..094f1138a6755 100644
--- a/addons/point_of_sale/static/tests/tours/ticket_screen_tour.js
+++ b/addons/point_of_sale/static/tests/tours/ticket_screen_tour.js
@@ -269,5 +269,13 @@ registry.category("web_tour.tours").add("LotTour", {
             inLeftSide({
                 trigger: ".info-list:contains('SN 3')",
             }),
+
+            // Verify if the serial number can be reused for the current order
+            Chrome.createFloatingOrder(),
+            ProductScreen.clickDisplayedProduct("Product A"),
+            ProductScreen.enterLastLotNumber("3"),
+            inLeftSide({
+                trigger: ".info-list:not(:contains('SN 3'))",
+            }),
         ].flat(),
 });