-
Notifications
You must be signed in to change notification settings - Fork 3
/
Copy pathVariation.h
165 lines (142 loc) · 4.02 KB
/
Variation.h
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
#ifndef _VARIATION_H
#define _VARIATION_H
#include <string>
#include <sstream>
#include <iostream>
/**
* Intermediate variant structure
*/
using namespace std;
class Variation {
public:
/**
* Variant count $cnt
*/
int varsCount;
/**
* Variant count on forward strand $dirPlus
*/
int varsCountOnForward;
/**
* Variant count on reverse strand $dirMinus
*/
int varsCountOnReverse;
/**
* Sum of variant positions in read $pmean
*/
double meanPosition;
/**
* Sum of base qualities for variant $qmean
*/
double meanQuality;
/**
* Sum of mapping qualities for variant $Qmean
*/
double meanMappingQuality;
/**
* Sum of number of mismatches for variant $nm
*/
double numberOfMismatches;
/**
* Number of low-quality reads with the variant $locnt
*/
int lowQualityReadsCount;
/**
* Number of high-quality reads with the variant $hicnt
*/
int highQualityReadsCount;
/**
* Flags that is true when variant is found in at least 2 different positions $pstd
*/
bool pstd;
/**
* Flags that is 1 when variant is read with at least 2 different qualities $qstd
*/
bool qstd;
/**
* Position in read for previous instance of this variant (used for pstd) $pp
*/
int pp;
/**
* Base quality for previous instance of this variant (used for qstd) $pq
*/
double pq;
/**
* Adjusted count for indels due to local realignment $extracnt
*/
int extracnt;
/**
* Increment count for direction
* @param dir false for forward strand, true for reverse strand
*/
void incDir(bool dir) {
if (dir)
this->varsCountOnReverse++;
else
this->varsCountOnForward++;
//std::cout << "address: " << static_cast<const void*>(this) << " - " << this->varsCountOnReverse<< std::endl;
}
/**
* Decrement count for direction
* @param dir false for forward strand, true for reverse strand
*/
void decDir(bool dir) {
if (dir)
this->varsCountOnReverse--;
else
this->varsCountOnForward--;
}
/**
* Get variant count for direction
* @param dir false for forward strand, true for reverse strand
* @return variant count
*/
int getDir(bool dir) {
if (dir)
return this->varsCountOnReverse;
return this->varsCountOnForward;
}
/**
* Add count for direction
* @param dir false for forward strand, true for reverse strand
* @param add amount of counts need to be added in the specific direction
*/
void addDir(bool dir, int add) {
if (dir)
this->varsCountOnReverse += add;
else
this->varsCountOnForward += add;
}
/**
* Subtract count for direction
* @param dir false for forward strand, true for reverse strand
* @param sub amount of counts need to be subtracted in the specific direction
*/
void subDir(bool dir, int sub) {
if (dir)
this->varsCountOnReverse -= sub;
else
this->varsCountOnForward -= sub;
}
string toString() {
stringstream ss;
ss << "Variation{" <<
"varsCount=" << varsCount <<
", varsCountOnForward=" << varsCountOnForward <<
", varsCountOnReverse=" << varsCountOnReverse <<
", meanPosition=" << meanPosition <<
", meanQuality=" << meanQuality <<
", meanMappingQuality=" << meanMappingQuality <<
", numberOfMismatches=" << numberOfMismatches <<
", lowQualityReadsCount=" << lowQualityReadsCount <<
", highQualityReadsCount=" << highQualityReadsCount <<
", pstd=" << pstd <<
", qstd=" << qstd <<
", pp=" << pp <<
", pq=" << pq <<
", extracnt=" << extracnt <<
'}';
return ss.str();
}
};
#endif