Releases: genome/somatic-sniper
SomaticSniper v1.0.5.0
Major Changes
This release alters how counts and average base qualities are reported in the VCF. Previous versions double counted ambiguous bases and improperly restricted the BCOUNT field to bases called in the tumor and normal genotypes (see #5). With this release, DP4 is now more stringent, only counting a read as a reference base if it matches that base exactly. BCOUNT is similarly more stringent and no longer reports ambiguous bases.
For calculating VAFs from the VCF output, we recommend using the BCOUNT field's value for your base of interest and dividing by the sum of the values in the BCOUNT field. This will prevent you from including ambiguous bases in your overall depth measure.
Minor Changes
CMAKE_INSTALL_PREFIXis now respected if specified during compilation.- A compilation error with unit tests on Max OS X (and possibly other platforms) was fixed.
- Numerous documentation updates
SomaticSniper v1.0.4.2
Major Changes
This is a patch release that fixes an edge case where the program would enter an infinite loop.
Minor Changes
- The source tree now support four digit versions and some documentation has been updated.
SomaticSniper v1.0.4
Major Changes
This release adds options to filter loss-of-heterozygosity and gain-of-reference allele calls from SomaticSniper output. Loss-of-heterozygosity calls are defined as calls where the tumor genotype is fully a subset of the normal genotype. Gain-of-heterozygosity calls are defined as those where the reference allele is not present in the normal genotype call, but is present in the tumor. For example the following calls would both be suppressed,
| Ref | Tumor | Normal |
|---|---|---|
| A | GG | AG |
| A | AG | GG |
Minor Changes
- build-common is now utilized as a git subtree. Downloads from github will now be functional and recursive clones are no longer necessary.
SomaticSniper v1.0.3
version v1.0.3
SomaticSniper v1.0.2
v1.0.2.3 doc update on filtering
SomaticSniper v1.0.1
v1.0.1 release
SomaticSniper v1.0.0
The latest release of SomaticSniper, The Genome Institute's somatic
SNV calling workhorse, adds an alternative statistical model that
better accounts for the rarity of somatic events by jointly
considering the tumor and normal genotypes. This version also adds
native support for the VCF and BED formats as output. The VCF output
contains information useful for downstream filtering, e. g., fraction
of reads on the forward and reverse strands, average read mapping
quality, and average base quality for reads/bases supporting the
variant allele and those supporting the reference allele.
SomaticSniper v0.7.4 Released
The purpose of this program is to identify single nucleotide positions that are different between tumor and normal (or, in theory, any two bam files). It takes a tumor bam and a normal bam and compares the two to determine the differences. It outputs a file in a format very similar to Samtools consensus format. It uses the genotype likelihood model of MAQ (as implemented in Samtools) and then calculates the probability that the tumor and normal genotypes are different. This probability is reported as a somatic score. The somatic score is the Phred-scaled probability (between 0 to 255) that the Tumor and Normal genotypes are not different where 0 means there is no probability that the genotypes are different and 255 means there is a probability of 1 – 10(255/-10) that the genotypes are different between tumor and normal. This is consistent with how the SAM format reports such probabilities.