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@scbirlab

SCBIR Lab

Systems Chemical Biology of Infection and Resistance Laboratory

Logo of SCBIR lab

The SCBIR lab is based the Francis Crick Institute in London. We use large-scale genetics and chemical biology to study how pathogenic bacteria infect and evolve resistance to antibiotics.

Ultimately, we aim to enable antimicrobial therapies which exploit key weaknesses in the ability of pathogenic bacteria to infect and evolve resistance to antibiotics.

Our work focuses on these areas (click the links for more information):

Find out more about our research here!

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  1. streq streq Public

    🧬 Python utilities for working with nucleotide sequence strings.

    Python

  2. nemony nemony Public

    🧠 Deterministically encode text as mnemonic adjective-noun pairs.

    Python 1

  3. monte-barcode monte-barcode Public

    🔴🟢🔵⚫️ Generating sets of random DNA sequences optimized for use in high-throughput sequencing.

    Python

  4. bioino bioino Public

    💻 Interconverting FASTA, GFF, and CSV.

    Python

  5. ogilo ogilo Public

    ⛓️ Automating construction of oligo library sequences for oligo array synthesis.

    Python

  6. hts-tools hts-tools Public

    🏮 Parsing and analysing platereader absorbance and fluorescence data.

    Python

Repositories

Showing 10 of 24 repositories
  • nf-sbrnaseq Public

    Nextflow pipeline to process demultiplexed Illumina paired-end FASTQ files from multiple bacterial samples into a gene x cell count table.

    scbirlab/nf-sbrnaseq’s past year of commit activity
    Nextflow 0 MIT 0 0 0 Updated Oct 15, 2024
  • nf-crispriseq Public

    Calculate fitness from massive competition experiments using CRISPRi-seq.

    scbirlab/nf-crispriseq’s past year of commit activity
    Nextflow 0 MIT 0 0 0 Updated Oct 14, 2024
  • crispio Public

    🌱 Designing CRISPRi experiments in bacteria

    scbirlab/crispio’s past year of commit activity
    Python 0 MIT 0 0 0 Updated Oct 14, 2024
  • schemist Public

    ⬢⬢⬢ Organizing and processing tables of chemical structures.

    scbirlab/schemist’s past year of commit activity
    Python 0 MIT 0 0 0 Updated Oct 12, 2024
  • hts-tools Public

    🏮 Parsing and analysing platereader absorbance and fluorescence data.

    scbirlab/hts-tools’s past year of commit activity
    Python 0 MIT 0 3 0 Updated Oct 7, 2024
  • nf-platereader-screen Public

    Process files from Biotek platereaders, normalise output, perform QC, make plots, and do statistical tests.

    scbirlab/nf-platereader-screen’s past year of commit activity
    Nextflow 0 MIT 0 0 0 Updated Oct 6, 2024
  • carabiner Public

    🪨 Useful python utilities.

    scbirlab/carabiner’s past year of commit activity
    Python 0 MIT 0 0 0 Updated Oct 5, 2024
  • abx-disco-dynamo Public

    Interface to demonstrate Figure 1 from https://doi.org/10.1042/BCJ20220062

    scbirlab/abx-disco-dynamo’s past year of commit activity
    Python 0 0 0 0 Updated Sep 27, 2024
  • nf-ggi Public

    Predict gene-gene interactions based on protein-protein interaction predictions and similar metabolites.

    scbirlab/nf-ggi’s past year of commit activity
    Nextflow 0 MIT 0 0 0 Updated Sep 22, 2024
  • yunta Public Forked from patrickbryant1/SpeedPPI

    🍐 Predicting protein-protein interactions and structures from multiple sequence alignments.

    scbirlab/yunta’s past year of commit activity
    Python 0 16 0 0 Updated Sep 22, 2024

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